ORKORAB DSR
ORKORAB DSR 20/30 mg Capsule is used to treat symptoms of acid reflux due to hyperacidity, stomach ulcer (Peptic ulcer disease), and Zollinger-Ellison syndrome (overproduction of acid due to a pancreatic tumour). Besides this, it is used short-term to treat gastroesophageal reflux disease (GERD) symptoms. GERD is a condition in which the sphincter (valve) located at the uppermost part of the stomach gets irritated and damaged due to excessive stomach acid production. As a result, the stomach acid and juice flow back into the food pipe, leading to stomach upset and heartburn. Heartburn is the post-effect of acid reflux with a burning-like feeling that rises from the stomach towards the neck.
ORKORAB DSR 20/30 mg Capsule contains two medicines, namely Rabeprazole and Domperidone. Rabeprazole is a proton pump inhibitor that helps reduce stomach acid by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). This gastric proton pump lies in the cells of the stomach wall. It is responsible for releasing gastric acid secretion and damaging tissues in the food pipe, stomach, and duodenum (uppermost part of the small intestine). On the other hand, Domperidone is a prokinetic agent that increases the motility of the upper gastrointestinal tract and blocks the vomiting-inducing centre (chemoreceptor trigger zone-CTZ).
Medicinal Benefits
ORKORAB DSR 20/30 mg Capsule helps in reducing the excess amount of stomach. In turn, it prevents the formation of an ulcer in the upper part of the intestine (duodenal ulcer), gastro-esophagal reflux disease (GERD) with or without ulcer and Zollinger-Ellison Syndrome, in which the stomach makes exceptionally high amounts of acid. Besides, the ORKORAB DSR 20/30 mg Capsule also treats symptoms of nausea and vomiting in adults and children over 12 years of age (with at least 35 kg or more).
- Rash
- Brittle bones
- Low vitamin B-12
- Loss of libido (sexual desire)
- Cough
- Sore throat
- Runny nose
- Flatulence (gas formation)
- Back pain
- Weakness or loss of strength
- Sleeplessness
- Headache
- Dizziness
- Benign polyps in the stomach
Directions for Use
Swallow it as a whole with water; do not crush, break or chew it.
Storage
Store in a cool and dry place away from sunlight
You should avoid taking ORKORAB DSR 20/30 mg Capsule if you are allergic to ORKORAB DSR 20/30 mg Capsule or proton pump inhibitors, have gastric cancer, liver disease, low magnesium level (osteoporosis), low vitamin B12, are pregnant or planning for pregnancy, and breastfeeding mothers. ORKORAB DSR 20/30 mg Capsule may interact with a blood thinner (warfarin), antifungal (ketoconazole), anti-HIV drug (atazanavir, nelfinavir), iron supplements, ampicillin antibiotic, anti-cancer drug (methotrexate). Let your doctor know if you are taking these medicines. Prolonged intake of ORKORAB DSR 20/30 mg Capsule may cause lupus erythematosus (an inflammatory condition in which the immune system attacks its tissues), Vitamin B-12, and magnesium deficiency. Intake of ORKORAB DSR 20/30 mg Capsule may mask the symptom of gastric cancer, so if you have any severe stomach pain or gastric bleeding (blood in mucous or stool), immediately consult the doctor. Tell your doctor that you are using before having a specific blood test known as Chromogranin A.
Therapeutic Class
GASTROINTESTINAL AGENTS
Drug-Drug Interactions: ORKORAB DSR 20/30 mg Capsule may interact with a blood thinner (clopidogrel, warfarin), antifungal (ketoconazole, voriconazole, itraconazole, fluconazole, posaconazole), anti-HIV drug (atazanavir, amprenavir, nelfinavir), antacid (magnesium hydroxide, aluminium hydroxide, cimetidine), iron supplements, antibiotics (clarithromycin, erythromycin, ampicillin, rifampicin), heart medicine (atropine, digoxin, amiodarone), blood pressure-lowering medicines (diltiazem), anti-cancer drug (methotrexate) and anti-nausea pills (aprepitant).
Drug-Food Interactions: ORKORAB DSR 20/30 mg Capsule interacts with St John’s wort plant that is used as an anti-depressant. This plant may affect the working of ORKORAB DSR 20/30 mg Capsule . So avoid its intake with ORKORAB DSR 20/30 mg Capsule .
Drug-Disease Interactions: ORKORAB DSR 20/30 mg Capsule should not be given in patients with C. difficile-induced colitis, liver disease, bone fractures, low Vitamin B12 (anaemia), and low magnesium (hypomagnesemia).
Drug-Drug Interactions Checker List
- CLOPIDOGREL
- WARFARIN
- KETOCONAZOLE
- VORICONAZOLE
- ITRACONAZOLE
- FLUCONAZOLE
- ATAZANAVIR
- AMPRENAVIR
- NELFINAVIR
- MAGNESIUM+ALUMINIUM HYDROXIDE
- CIMETIDINE
- IRON
- ERYTHROMYCIN
- RIFAMPICIN
- ATROPINE
- DIGOXIN
- AMIODARONE
- DILTIAZEM
- METHOTREXATE
- CLARITHROMYCIN
Diet & Lifestyle Advise
- Avoid intake of acid or heartburn-triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes and high-fat and spicy foods.
- Avoid taking alcohol and smoking cigarette. Alcohol can raise the level of production of stomach acid leading to heartburn and acid reflux. On the other hand, nicotine smoking damages the valve (sphincter), preventing stomach acid backflow into the food pipe.
- Avoid regular sitting continuously, as it can increase stomach acid production. Try to take a break of 5 minutes in 1 hour by brisk walking or stretching.
- Before going to sleep, try to raise your bedhead so that your head and chest are higher than your feet. Do not use piles of pillows, instead, one raised block is fine. This will not allow the stomach acid to backflow through your food pipe.
- Include high fibre containing foods, berries, cherries, leafy green veggies (kale, spinach) and black peppers in your meal. These foods are full of antioxidants, calcium and vitamin B 12 that can help cope with the long-term effects of the medicine. Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics which help in the prevention of excess stomach acid production. Cranberry juice can be beneficial in the peptic ulcer and H Pylori infection.
Habit Forming
No
What if I have taken an overdose of ORKORAB DSR 20/30 mg Capsule
Do not take more than the prescribed dose of ORKORAB DSR 20/30 mg Capsule as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.
Special Advise
- Do not take ORKORAB DSR 20/30 mg Capsule for more than four weeks of duration without consulting the doctor.
